Pathology considerations for, and subsequent risk assessment of, chemicals identified as immunosuppressive in routine toxicology.

@article{Basketter1995PathologyCF,
  title={Pathology considerations for, and subsequent risk assessment of, chemicals identified as immunosuppressive in routine toxicology.},
  author={David A Basketter and Jeff N. Bremmer and Penelope Buckley and M E Kammuller and Toshinobu Kawabata and I A N Kimber and Scott E Loveless and S J Magda and David Alexander Stringer and H. W. Vohr},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={1995},
  volume={33 3},
  pages={239-43}
}
Several proposals have been made with the aim of assisting in the early identification of chemicals with immunotoxic potential. The Organisation for Economic Cooperation and Development is now likely to incorporate enhanced immunopathology into the test guideline for the 28-day rat study, which may be regarded as a Tier I investigation. However, no guidelines have yet been proposed either for how the new data generated will be evaluated, or for how a subsequent risk assessment will be made. In… CONTINUE READING