Pathology and pathogenesis of vascular cognitive impairment—a critical update

  title={Pathology and pathogenesis of vascular cognitive impairment—a critical update},
  author={Kurt A. Jellinger},
  booktitle={Front. Aging Neurosci.},
Vascular cognitive impairment (VCI) [vascular cognitive disorder (VCD), vascular dementia] describes a continuum of cognitive disorders ranging from mild cognitive impairment (MCI) to dementia, in which vascular brain injury involving regions important for memory, cognition and behavior plays an important role. Clinical diagnostic criteria show moderate sensitivity (ca 50%) and variable specificity (range 64-98%). In Western clinical series, VaD is suggested in 8-10% of cognitively impaired… CONTINUE READING
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