Pathology and molecular biology of gastric cancer.

  title={Pathology and molecular biology of gastric cancer.},
  author={Matti Vauhkonen and Hanna Vauhkonen and Pentti Ilmari Sipponen},
  journal={Best practice & research. Clinical gastroenterology},
  volume={20 4},
Several attempts to classify gastric cancer (GCA) have been made over the past decades. Most successful, and widely used, is the classification by Laurén, which distinguishes, by microscopical morphology alone, two main cancer pathogeneses, diffuse (DGCA) and intestinal (IGCA) subtypes, which appear clearly as dissimilar clinical and epidemiological entities. Here we review the main differences in epidemiology, histopathology, and molecular pathology of the two main subtypes of gastric… CONTINUE READING