Pathologically activated therapeutics for neuroprotection

@article{Lipton2007PathologicallyAT,
  title={Pathologically activated therapeutics for neuroprotection},
  author={S. Lipton},
  journal={Nature Reviews Neuroscience},
  year={2007},
  volume={8},
  pages={803-808}
}
  • S. Lipton
  • Published 2007
  • Medicine
  • Nature Reviews Neuroscience
Many drugs that have been developed to treat neurodegenerative diseases fail to gain approval for clinical use because they are not well tolerated in humans. In this article, I describe a series of strategies for the development of neuroprotective therapeutics that are both effective and well tolerated. These strategies are based on the principle that drugs should be activated by the pathological state that they are intended to inhibit. This approach has already met with success, and has led to… Expand
158 Citations
Pathologically activated therapeutics for neuroprotection
  • S. Lipton
  • Philosophy, Medicine
  • Nature Reviews Neuroscience
  • 2007
  • 74
  • PDF
Receptor abuse-dependent antagonism for neuroprotection
  • H. Manev
  • Biology
  • Nature Reviews Neuroscience
  • 2007
  • PDF
Therapeutic potential of mGluR5 targeting in Alzheimer's disease
  • 42
Ginsenoside Rd for acute ischemic stroke: translating from bench to bedside
  • 32
Neuroprotection for ischemic stroke: Past, present and future
  • 674
Neuroprotection against excitotoxic and ischemic insults by bis(12)-hupyridone, a novel anti-acetylcholinesterase dimer, possibly via acting on multiple targets
  • 13
  • Highly Influenced
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 81 REFERENCES
Paradigm shift in neuroprotection by NMDA receptor blockade: Memantine and beyond
  • S. Lipton
  • Chemistry, Medicine
  • Nature Reviews Drug Discovery
  • 2006
  • 723
NMDA receptor pathways as drug targets
  • 428
The chemical biology of clinically tolerated NMDA receptor antagonists
  • Huei‐Sheng Vincent Chen, S. Lipton
  • Medicine
  • Journal of neurochemistry
  • 2006
  • 410
  • PDF
NMDA Receptors, Glial Cells, and Clinical Medicine
  • 77
Emerging treatments for stroke in humans.
  • 192
Excitatory amino acid neurotoxicity and neurodegenerative disease.
  • 1,773
Emerging biological roles for erythropoietin in the nervous system
  • 301
Pathways towards and away from Alzheimer's disease
  • 2,531
  • PDF
Erythropoietin Therapy for Acute Stroke Is Both Safe and Beneficial
  • 1,002
  • PDF
...
1
2
3
4
5
...