Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A

@inproceedings{Sonnenberg2010PathologicalVP,
  title={Pathological versus protective functions of IL-22 in airway inflammation are regulated by IL-17A},
  author={Gregory F Sonnenberg and Meera G Nair and Thomas J. Kirn and Colby Zaph and Lynette A. Fouser and David Artis},
  booktitle={The Journal of experimental medicine},
  year={2010}
}
IL-22 has both proinflammatory and tissue-protective properties depending on the context in which it is expressed. However, the factors that influence the functional outcomes of IL-22 expression remain poorly defined. We demonstrate that after administration of a high dose of bleomycin that induces acute tissue damage and airway inflammation and is lethal to wild-type (WT) mice, Th17 cell-derived IL-22 and IL-17A are expressed in the lung. Bleomycin-induced disease was ameliorated in Il22… CONTINUE READING

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