Pathological study of otitis media with effusion after treatment with intranasal pulmonary surfactant

@article{Zhu2013PathologicalSO,
  title={Pathological study of otitis media with effusion after treatment with intranasal pulmonary surfactant},
  author={Zheng Hua Zhu and Ying Jun Shan and Yang Han and Lanjian Zhu and Zhao Xin Ma},
  journal={The Laryngoscope},
  year={2013},
  volume={123}
}
To evaluate the histopathological effect of intranasal pulmonary surfactant (PS) on the eustachian tube (ET) in guinea pigs with otitis media with effusion (OME). 
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13 Citations
Background Citations
4
Methods Citations
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13 Citations

Citation Type

Citation Type

Nasal Mucociliary Clearance in Adenoid Hypertrophy and Otitis Media with Effusion
  • H. Yazici
  • Medicine
    Current Allergy and Asthma Reports
  • 2015
Mucociliary clearance (MCC), which exists in many systems, is the first defensive mechanism of the human body. Nasal MCC has an important role in transporting the secretions of the nasal cavity and…
Otitis Media with Effusion, Development of Animal Model: Literature Review
TLDR
Althought different animal models had been established as model, none of them were able to explain in detail about the disease physiology in animal and further more research is needed to develop a valid animal model of otitis media with effusion.
Eustachian Tube Dysfunction, Eosinophilic Otitis Media, Endolymphatic Hydrops, and the Role of Allergic Rhinitis
TLDR
Current evidence supporting the relationship between allergies and eustachian tube dysfunction (ETD), eosinophilic otitis media (EOM), and endolymphatic hydrops is summarized and reviewed.
Immunoglobulins and Transcription Factors in Otitis Media
TLDR
B cell leukemia/lymphoma-6 and paired box gene 5 (Pax-5) suppress antibody production, whereas B lymphocyte inducer of maturation program 1 (Blimp-1 and X-box binding protein 1 (XBP-1) promote antibody production during immune responses in patients with otitis media.
Animal models of acute otitis media - A review with practical implications for laboratory research.
Effects of combination of balloon Eustachian tuboplasty with methylprednisolone irrigation on treatment of chronic otitis media with effusion in adults.
Toll-Like Receptors: Expression and Roles in Otitis Media
TLDR
Inappropriate TLR expression, or delayed or absent induction, are associated with the occurrence, recurrence, chronicization, and complications of otitis media.
Extrapulmonary Surfactant Therapy: Review of Available Data and Research/Development Issues
TLDR
This work comprehensively review the data about surfactant biology and pharmacology in organs other than the lung, especially focusing in the more promising Surfactant extrapulmonary roles.
Lung Surfactant Lipids Provide Immune Protection Against Haemophilus influenzae Respiratory Infection
TLDR
Administration of the hydrophobic fraction of lung surfactant in vivo accelerated bacterial clearance in a mouse model of NTHi pulmonary infection is supported, supporting the notion that the lipid component of lung Surfactant protects against N THi infection.
Panel 2: Anatomy (Eustachian Tube, Middle Ear, and Mastoid—Anatomy, Physiology, Pathophysiology, and Pathogenesis)
  • C. Alper, M. Luntz, +7 authors D. Poe
  • Medicine
    Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
  • 2017
TLDR
Whether the short-term goals elaborated in the last report were achieved are determined, and updated goals to guide future otitis media research are proposed.
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References

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Intranasal Surfactant Aerosol Therapy for Otitis Media With Effusion
Objective To determine the effect of surfactant alone and with other medications delivered intranasally as a metered dose inhaler (MDI) aerosol on the resolution of e‐perimentally induced otitis…
Otitis Media: Treatment With Intranasal Aerosolized Surfactant
Objectives/Hypothesis The objective was to determine the effect of intranasal surfactant alone and with other medications administered by metered dose inhaler aerosol on the function of the…
Nebulized surfactant as a treatment choice for otitis media with effusion: an experimental study in the rabbit
TLDR
A significant improvement in the negative middle-ear pressure after nebulized surfactant treatment and the histological findings shown in this study can support the theory that surface-active agents are of importance in eustachian tube function even under pathologic conditions, such as OME.
Protective effect of pulmonary surfactant on cilia of Eustachian tube in otitis media with effusion.
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Effect of Nebulized Bovine Surfactant for Experimental Otitis Media with Effusion
TLDR
The results suggest that the chosen nebulized bovine pulmonary surfactant can be of good clinical benefit for treating OME in the future and play an important role in treating otitis media with effusion in guinea pigs.
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TLDR
The prevalence of otitis media with effusion in urban Chinese children in Xi'an is not high in comparison with that of the same age group in surrounding areas and shows no statistically significant difference between genders or between ear sides.
Clinical and ultrastructural correlations in nasal mucociliary function observed in children with recurrent airways infections.
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