Pathological sprouting of adult nociceptors in chronic prostate cancer-induced bone pain.

  title={Pathological sprouting of adult nociceptors in chronic prostate cancer-induced bone pain.},
  author={Juan Miguel Jim{\'e}nez-Andrade and Aaron P Bloom and James I Stake and William G Mantyh and Reid N Taylor and Katie T. Freeman and Joseph R. Ghilardi and Michael A. Kuskowski and Patrick W Mantyh},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={30 44},
Pain frequently accompanies cancer. What remains unclear is why this pain frequently becomes more severe and difficult to control with disease progression. Here we test the hypothesis that with disease progression, sensory nerve fibers that innervate the tumor-bearing tissue undergo a pathological sprouting and reorganization, which in other nonmalignant pathologies has been shown to generate and maintain chronic pain. Injection of canine prostate cancer cells into mouse bone induces a… CONTINUE READING
48 Citations
56 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 48 extracted citations


Publications referenced by this paper.
Showing 1-10 of 56 references

The incidence of complex regional pain syndrome: a population-based study. Pain 129:12–20

  • M de Mos, AG de Bruijn, FJ Huygen, JP Dieleman, BH Stricker, MC Sturkenboom
  • 2007
Highly Influential
1 Excerpt

Similar Papers

Loading similar papers…