Pathological situations characterized by altered actin isoform expression.

  title={Pathological situations characterized by altered actin isoform expression.},
  author={Christine Chaponnier and Giulio Gabbiani},
  journal={The Journal of pathology},
  volume={204 4},
Modulation of actin isoform expression is a well-established feature of developmental phenomena. As one might expect, it is also characteristic of several pathological situations that are the subject of the present review. alpha-Smooth muscle actin has proven to be a reliable marker for identifying (a) vascular smooth muscle cells during vascular development and vascular diseases, and (b) myofibroblasts during wound healing, fibrocontractive diseases, and stromal reaction to epithelial tumours… CONTINUE READING