Pathological rate matrices: from primates to pathogens

Abstract

Continuous-time Markov models allow flexible, parametrically succinct descriptions of sequence divergence. Non-reversible forms of these models are more biologically realistic but are challenging to develop. The instantaneous rate matrices defined for these models are typically transformed into substitution probability matrices using a matrix exponentiation… (More)
DOI: 10.1186/1471-2105-9-550

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