Pathological niche environment transforms dermal stem cells to keloid stem cells: a hypothesis of keloid formation and development.

@article{Qu2013PathologicalNE,
  title={Pathological niche environment transforms dermal stem cells to keloid stem cells: a hypothesis of keloid formation and development.},
  author={Miao Qu and Nang Hee Song and G. W. K. Chai and Xiaoli Wu and Wei Liu},
  journal={Medical hypotheses},
  year={2013},
  volume={81 5},
  pages={807-12}
}
Keloid is a disease that is difficult to cure because of its high recurrence rate after chemotherapy or radiotherapy, therefore it is considered as a benign skin tumor. Tumor stem cells are proposed as the source for tumor development and post-therapy recurrence. Interestingly, keloid stem cells have also been discovered, which share some characters with those of skin progenitor cells. Keloid patients possess specific diathesis including genetic predisposition and gene mutation, abnormal levels… CONTINUE READING

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