Pathological laughing and crying in multiple sclerosis: a preliminary report suggesting a role for the prefrontal cortex.

@article{Feinstein1999PathologicalLA,
  title={Pathological laughing and crying in multiple sclerosis: a preliminary report suggesting a role for the prefrontal cortex.},
  author={A Feinstein and P. K. O'Connor and Trevor Gray and Karen Wolk Feinstein},
  journal={Multiple sclerosis},
  year={1999},
  volume={5 2},
  pages={69-73}
}
As part of a wide ranging study investigating the prevalence, demographic and disease related characteristics of pathological laughing and crying (PLC) in multiple sclerosis (MS), a putative role for the prefrontal cortex was also explored. Eleven multiple sclerosis (MS) patients with carefully defined PLC were compared to a control group of 13 MS patients without PLC on various cognitive indices known to be sensitive to frontal lobe dysfunction. Although the two groups did not differ with… CONTINUE READING

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