Pathological laughing and crying in amyotrophic lateral sclerosis: an association with prefrontal cognitive dysfunction

@article{McCullagh1999PathologicalLA,
  title={Pathological laughing and crying in amyotrophic lateral sclerosis: an association with prefrontal cognitive dysfunction},
  author={S. McCullagh and Myrna Moore and M. Gawel and A. Feinstein},
  journal={Journal of the Neurological Sciences},
  year={1999},
  volume={169},
  pages={43-48}
}
  • S. McCullagh, Myrna Moore, +1 author A. Feinstein
  • Published 1999
  • Psychology, Medicine
  • Journal of the Neurological Sciences
  • Pathological laughing and crying (PLC) frequently occurs in amyotrophic lateral sclerosis (ALS). The etiology of the syndrome is unclear, but frontal-subcortical circuits are implicated, given their known association with mood and affect regulation. Ten ALS patients with PLC, eight patients without, and ten healthy controls were compared on a number of psychometric measures. Three indices of prefrontal cortical function were given: the Wisconsin Card Sort Test (WCST), the novel 'Gambling task… CONTINUE READING
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