Pathological laughing and crying in amyotrophic lateral sclerosis: an association with prefrontal cognitive dysfunction

  title={Pathological laughing and crying in amyotrophic lateral sclerosis: an association with prefrontal cognitive dysfunction},
  author={Scott McCullagh and Myrna Moore and Marek J. Gawel and Anthony Feinstein},
  journal={Journal of the Neurological Sciences},

The association of pathological laughing and crying and cognitive impairment in multiple sclerosis

Pathological laughing and crying in amyotrophic lateral sclerosis is related to frontal cortex function

Physiological reactions as well as behavioural changes suggest that this phenomenon is primarily an expression of reduced inhibitory activity of the frontal cortex, since frontal dysfunction could explain changes in physiological parameters in the patient group.

Only subtle cognitive deficits in non–bulbar amyotrophic lateral sclerosis patients

The results support the view that there are only subtle cognitive deficits in ALS patients and assume a possible effect of practice on cognitive tasks following reduced daily motor activity.

Investigating the neuroanatomical substrate of pathological laughing and crying in amyotrophic lateral sclerosis with multimodal neuroimaging techniques

PLC in ALS is driven by both GM and WM abnormalities which highlight the role of circuits rather than isolated centers in the emergence of this condition.

Laughter, crying and sadness in ALS

  • N. ThakoreE. Pioro
  • Psychology, Medicine
    Journal of Neurology, Neurosurgery, and Psychiatry
  • 2017
This study identifies associations of PBA and additionally finds PBA (especially crying-predominant PBA) more prevalent in women with ALS and finds significant overlap between depression and crying in PBA.

Emotional responding in amyotrophic lateral sclerosis

It is concluded that emotional responses of ALS patients tend to be altered towards positive valence and towards a more balanced arousal state in early stages of the disease, contradict assumptions of a generally negative impact of the Disease on the emotional disposition and may indicate compensatory cognitive or neuroplastic changes.

Alternative cognitive therapy for emotional instability (pathologic laughing and crying).

  • A. Kasprisin
  • Psychology, Biology
    Physical medicine and rehabilitation clinics of North America
  • 2004

Pathological Crying and Laughing in Motor Neuron Disease: Pathobiology, Screening, Intervention

Emerging neuroimaging studies of ALS support the role of cortico–pontine–cerebellar network dysfunction in context-inappropriate emotional responses and the characterization of PCL-associated pathophysiological processes is indispensable for the development of effective pharmacological therapies.

[Emotions and amyotrophic lateral sclerosis: a psychopathological perspective].

  • C. Bungener
  • Psychology
    Geriatrie et psychologie neuropsychiatrie du vieillissement
  • 2012
Assessment of the emotional processing used by ALS patients should improve the comprehension of their adaptive functioning and the perceived social support of the patients' caregivers.



Pathological laughing and crying in multiple sclerosis: a preliminary report suggesting a role for the prefrontal cortex

As part of a wide ranging study investigating the prevalence, demographic and disease related characteristics of pathological laughing and crying (PLC) in multiple sclerosis (MS), a putative role for

Neuropsychological dysfunctions in amyotrophic lateral sclerosis: relation to motor disabilities.

There was a significant negative correlation between upper motor neuron symptoms and MMS, as well as memory tests, which revealed that more sensitive neuropsychological measurements might reveal cerebral dysfunction in ALS patients who are not presenting evident dementia.

Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis.

This study elicited cognitive deficits (involving predominantly executive processes, with some evidence of memory impairment) in patients with ALS and further strengthened the link between ALS and frontal lobe dysfunction, this being more prominent in Patients with pseudobulbar palsy.

Prevalence and correlates of neuropsychological deficits in amyotrophic lateral sclerosis.

Neither the conventional wisdom that cognition is intact in nearly all patients with amyotrophic lateral sclerosis, nor more recent suggestions that Cognition is often at least mildly impaired seems to be correct.


Amyotrophic lateral sclerosis is a disease characterized by: (1) muscular atrophy with fibrillary twitchings, (2) spasticity with evidence of lesions of the upper motor neurons and (3) symptoms of

Pathological Laughing and Crying

Clinicians should remain vigilant for attacks of involuntary, irresistible laughing or crying, and offer effective treatments, such as antidepressants, where indicated, when indicated.

Cognitive function in amyotrophic lateral sclerosis

Frontal lobe dysfunction in Parkinson's disease. The cortical focus of neostriatal outflow.

The validity of an outflow model in predicting the consequences of caudate nucleus dysfunction was supported and a small cluster of deficits emerged, interpreted as reflecting impairment in the ability to spontaneously generate efficient strategies when relying on self-directed task-specific planning.

Pathologic laughter and crying in ALS: a search for their origin

A study was made of the incidence of pathologic laughter and crying in patients whose motor neuron disease had started before the age of 45 years, finding the youngest patient with spells was 31 when his illness began and 35 when he started to have bouts of crying.