Pathological laughing and crying in amyotrophic lateral sclerosis: an association with prefrontal cognitive dysfunction

@article{McCullagh1999PathologicalLA,
  title={Pathological laughing and crying in amyotrophic lateral sclerosis: an association with prefrontal cognitive dysfunction},
  author={Scott McCullagh and Myrna Moore and Marek J. Gawel and Anthony Feinstein},
  journal={Journal of the Neurological Sciences},
  year={1999},
  volume={169},
  pages={43-48}
}

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...

References

SHOWING 1-10 OF 43 REFERENCES

Pathological laughing and crying in multiple sclerosis: a preliminary report suggesting a role for the prefrontal cortex

As part of a wide ranging study investigating the prevalence, demographic and disease related characteristics of pathological laughing and crying (PLC) in multiple sclerosis (MS), a putative role for

Neuropsychological dysfunctions in amyotrophic lateral sclerosis: relation to motor disabilities.

TLDR
There was a significant negative correlation between upper motor neuron symptoms and MMS, as well as memory tests, which revealed that more sensitive neuropsychological measurements might reveal cerebral dysfunction in ALS patients who are not presenting evident dementia.

Relation between cognitive dysfunction and pseudobulbar palsy in amyotrophic lateral sclerosis.

TLDR
This study elicited cognitive deficits (involving predominantly executive processes, with some evidence of memory impairment) in patients with ALS and further strengthened the link between ALS and frontal lobe dysfunction, this being more prominent in Patients with pseudobulbar palsy.

Prevalence and correlates of neuropsychological deficits in amyotrophic lateral sclerosis.

TLDR
Neither the conventional wisdom that cognition is intact in nearly all patients with amyotrophic lateral sclerosis, nor more recent suggestions that Cognition is often at least mildly impaired seems to be correct.

PSYCHOTIC AND EMOTIONAL PHENOMENA ASSOCIATED WITH AMYOTROPHIC LATERAL SCLEROSIS

Amyotrophic lateral sclerosis is a disease characterized by: (1) muscular atrophy with fibrillary twitchings, (2) spasticity with evidence of lesions of the upper motor neurons and (3) symptoms of

Pathological Laughing and Crying

TLDR
Clinicians should remain vigilant for attacks of involuntary, irresistible laughing or crying, and offer effective treatments, such as antidepressants, where indicated, when indicated.

Cognitive function in amyotrophic lateral sclerosis

Frontal lobe dysfunction in Parkinson's disease. The cortical focus of neostriatal outflow.

TLDR
The validity of an outflow model in predicting the consequences of caudate nucleus dysfunction was supported and a small cluster of deficits emerged, interpreted as reflecting impairment in the ability to spontaneously generate efficient strategies when relying on self-directed task-specific planning.

Pathologic laughter and crying in ALS: a search for their origin

TLDR
A study was made of the incidence of pathologic laughter and crying in patients whose motor neuron disease had started before the age of 45 years, finding the youngest patient with spells was 31 when his illness began and 35 when he started to have bouts of crying.