Pathological features of different sizes of nickel oxide following intratracheal instillation in rats.

@article{Ogami2009PathologicalFO,
  title={Pathological features of different sizes of nickel oxide following intratracheal instillation in rats.},
  author={Akira Ogami and Yasuo Morimoto and Toshihiko Myojo and Takako Oyabu and Masahiro Murakami and Motoi Todoroki and Kenichiro Nishi and Chikara Kadoya and Makoto Yamamoto and Isamu Tanaka},
  journal={Inhalation toxicology},
  year={2009},
  volume={21 10},
  pages={812-8}
}
Focusing on the "size" impact of particles, the objective of this study was to analyze morphological and qualitative changes over time in the development of inflammation and collagen deposition in lung tissue after intratracheal instillation of two sizes of nickel oxide in rats, in comparison with the results of instillation of crystalline silica and titanium dioxide. The fine-sized nickel oxide sample (nNiOm: median diameter of agglomerated particles 0.8 microm) was prepared from crude… CONTINUE READING

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