Pathological effect of IL-17A-producing TCRγδ(+) T cells in mouse genital mucosa against HSV-2 infection.

@article{Kim2012PathologicalEO,
  title={Pathological effect of IL-17A-producing TCRγδ(+) T cells in mouse genital mucosa against HSV-2 infection.},
  author={Jae-Ouk Kim and Hye-Ran Cha and Eun-Do Kim and M S Kweon},
  journal={Immunology letters},
  year={2012},
  volume={147 1-2},
  pages={34-40}
}
Interleukin (IL)-17A is a cytokine that plays an important role in infectious, autoimmune, and inflammatory diseases. In this study, we found that TCRγδ(+)CD4(-)CD8(-) T cells, but not TCRαβ(+)CD4(+) T cells, are the primary producers of IL-17A in the genital tract of female mice in the steady-state condition. High mRNA levels of IL-17A and RORγt were… CONTINUE READING