Pathological correlations of [F-18]-AV-1451 imaging in non-alzheimer tauopathies.

  title={Pathological correlations of [F-18]-AV-1451 imaging in non-alzheimer tauopathies.},
  author={Marta Marqui{\'e} and Marc D. Normandin and Avery C Meltzer and Michael Siao Tick Chong and Nicolas V Andrea and Alejandro Ant{\'o}n-Fern{\'a}ndez and William E. Klunk and Chester A. Mathis and Milos D. Ikonomovic and Manik L. Debnath and Elizabeth Ann Bien and Charles R. Vanderburg and Isabel M. Costantino and Sara J Makaretz and Sarah L DeVos and Derek H. Oakley and Stephen N. Gomperts and John Growdon and Kimiko Domoto-Reilly and Diane E Lucente and Bradford C. Dickerson and Matthew P. Frosch and Bradley T. Hyman and Keith A. Johnson and Teresa G{\'o}mez-Isla},
  journal={Annals of neurology},
  volume={81 1},
OBJECTIVE Recent studies have shown that positron emission tomography (PET) tracer AV-1451 exhibits high binding affinity for paired helical filament (PHF)-tau pathology in Alzheimer's brains. However, the ability of this ligand to bind to tau lesions in other tauopathies remains controversial. Our goal was to examine the correlation of in vivo and postmortem AV-1451 binding patterns in three autopsy-confirmed non-Alzheimer tauopathy cases. METHODS We quantified in vivo retention of [F-18]-AV… CONTINUE READING
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