Pathological changes in tight junctions and potential applications into therapies.

Abstract

Epithelial cells are pivotal in the separation of the body from the outside environment. Orally administered drugs must pass across epithelial cell sheets, and most pathological organisms invade the body through epithelial cells. Tight junctions (TJs) are sealing complexes between adjacent epithelial cells. Modulation of TJ components is a potent strategy… (More)
DOI: 10.1016/j.drudis.2012.02.014

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