Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's disease

@article{Gu2007PathologicalCI,
  title={Pathological cell-cell interactions are necessary for striatal pathogenesis in a conditional mouse model of Huntington's disease},
  author={Xiaofeng Gu and V{\'e}ronique Marie Andr{\'e} and Carlos Cepeda and Shihua Li and Xiao-Jiang Li and Michael S Levine and X William Yang},
  journal={Molecular Neurodegeneration},
  year={2007},
  volume={2},
  pages={8 - 8}
}
A critical issue in understanding Huntington's disease (HD) pathogenesis is how the ubiquitously expressed mutant huntingtin (mhtt) with an expanded polyglutamine repeat can cause selective toxicity of striatal and cortical neurons. Two potential cellular models may contribute to such specificity: expression of mhtt in these vulnerable neurons alone may be sufficient to result in their dysfunction and/or degeneration (cell-autonomous model); or mhtt in other cell types can elicit pathological… CONTINUE READING