Pathological angiogenesis is reduced by targeting pericytes via the NG2 proteoglycan

@article{Ozerdem2004PathologicalAI,
  title={Pathological angiogenesis is reduced by targeting pericytes via the NG2 proteoglycan},
  author={Ugur Ozerdem and William B Stallcup},
  journal={Angiogenesis},
  year={2004},
  volume={7},
  pages={269-276}
}
The NG2 proteoglycan is expressed by nascent pericytes during the early stages of angiogenesis. To investigate the functional role of NG2 in neovascularization, we have compared pathological retinal and corneal angiogenesis in wild type and NG2 null mice. During ischemic retinal neovascularization, ectopic vessels protruding into the vitreous occur twice as frequently in wild type retinas as in NG2 null retinas. In the NG2 knock-out retina, proliferation of both pericytes and endothelial cells… CONTINUE READING