Pathological and clinical significance of increased intraepithelial lymphocytes (IELs) in small bowel mucosa.

@article{Chang2005PathologicalAC,
  title={Pathological and clinical significance of increased intraepithelial lymphocytes (IELs) in small bowel mucosa.},
  author={Fuju Chang and Ula Mahadeva and Harriet Deere},
  journal={APMIS : acta pathologica, microbiologica, et immunologica Scandinavica},
  year={2005},
  volume={113 6},
  pages={385-99}
}
Intestinal intraepithelial lymphocytes (IELs) belong to a unique T-cell population interspersed between epithelial cells of both the small and large intestine. It is becoming increasingly recognised that an increased number of IELs with a normal villous architecture is within the wide spectrum of histological abnormalities observed in coeliac disease. An increased number of IELs is the earliest pathological change following gluten challenge and a high IEL count may be the only sign of gluten… CONTINUE READING
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