Pathological and biochemical features of Legionella pneumophila infection in guinea-pigs.

@article{Hambleton1982PathologicalAB,
  title={Pathological and biochemical features of Legionella pneumophila infection in guinea-pigs.},
  author={Peter Hambleton and A B Baskerville and R. B. Fitzgeorge and Nigel J.L Bailey},
  journal={Journal of medical microbiology},
  year={1982},
  volume={15 3},
  pages={
          317-26
        }
}
The main pathological feature of experimental legionellosis produced by the intraperitoneal inoculation of guinea-pigs was a fibrinopurulent peritonitis, especially over the liver and spleen. Foci of necrosis were present in these organs from the second to seventh day after infection. Early biochemical changes in the serum included significant decreases in the concentration of zinc and iron, and increases in copper and triglycerides. Phenylalanine to tyrosine ratios increased strikingly, but… CONTINUE READING

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