Pathological and Toxicological Findings in Glyphosate-Surfactant Herbicide Fatality: A Case Report

@article{Sribanditmongkol2012PathologicalAT,
  title={Pathological and Toxicological Findings in Glyphosate-Surfactant Herbicide Fatality: A Case Report},
  author={Pongruk Sribanditmongkol and Prapan Jutavijittum and Pattaravadee Pongraveevongsa and Klintean Wunnapuk and Piya Durongkadech},
  journal={The American Journal of Forensic Medicine and Pathology},
  year={2012},
  volume={33},
  pages={234–237}
}
AbstractGlyphosate herbicide is promoted by the manufacturer as having no risks to human health, with acute toxicity being very low in normal use. In Thailand, however, poisoning from glyphosate agricultural herbicides has been increasing. A case of rapid lethal intoxication from glyphosate-surfactant herbicide involved a 37-year-old woman, who deliberately ingested approximately 500 mL of concentrated Roundup formulation (41% glyphosate as the isopropylamine salt and 15% polyoxyethylene amine… 
Toxicity, Biodegradability and Detection Methods of Glyphosate; the Most Used Herbicide: A Systematic Review
Introduction: Glyphosate is known as the most used world's herbicides and contradictions exist over its classification as a probably carcinogenic for the human. This study aimed to review the newest
Determination of glyphosate and its metabolite in emergency room in Korea.
Subchronic exposure to a glyphosate-based herbicide causes dysplasia in the digestive tract of Wistar rats
TLDR
The data indicate that GBH causes oral allergies and dysplastic lesions in the oesophagus and small and large intestine and has genotoxic potential.
Nephrotoxicity of Kalach 360 SL: biochemical and histopathological findings
TLDR
The chronic exposure to KL induced an increase in lipid peroxidation (LPO) and a decrease in antioxidant status, enzymatic activities (superoxide dismutase and catalase) and non-enzymatic levels (vitamin C), which led to an oxidative stress.
Glyphosate in Agriculture: Environmental Persistence and Effects on Animals. A Review
Glyphosate, in the history of agriculture, is one of the most commonly used herbicide, due to its high effectiveness and low cost compared to other solutions. Glyphosate based herbicides (GBHs),
Spectrum of corrosive esophageal injury after intentional paraquat or glyphosate-surfactant herbicide ingestion
TLDR
Patients with grade 2b esophageal injury suffered from a greater incidence of respiratory and gastrointestinal complications than patients with grade 1 injury, regardless of herbicide type, and the data suggest a potential relationship between the degree of esophagal injury and systemic complications.
Seizures in patients with acute pesticide intoxication, with a focus on glufosinate ammonium
TLDR
Glufosinate ammonium herbicide is the most common seizurogenic pesticide class and seizure itself was not a risk factor for mortality in patients with acute glufosinated ammonium intoxication, according to the pesticide class.
Dialyzability of Surfactants Commonly Used in Pesticide Formulations
TLDR
The results suggest that extracorporeal elimination may be an effective treatment modality in patients who ingested surfactant mixed pesticides, however, the dialysis method looks likely to be tailored to each surfactants, based on its dialyzability.
...
...

References

SHOWING 1-10 OF 23 REFERENCES
Acute Poisoning with a Glyphosate-Surfactant Herbicide ('Roundup'): A Review of 93 Cases
TLDR
There were seven deaths following ingestion of 'Roundup' alone, due to a syndrome that involved hypotension, unresponsive to intravenous fluids or vasopressor drugs, and sometimes pulmonary oedema, in the presence of normal central venous pressure.
Clinical presentations and prognostic factors of a glyphosate-surfactant herbicide intoxication: a review of 131 cases.
TLDR
In managing patients who have larger amount of GlySH ingestion, airway protection, early detection of pulmonary edema, and prevention of further pulmonary damage and renal damage appear to be of critical importance.
Taiwan National Poison Center survey of glyphosate--surfactant herbicide ingestions.
TLDR
Between January, 1986 and September, 1988, the Taiwan National Poison Center recorded 97 telephone consultations on cases of ingestion of glyphosate-surfactant herbicide concentrate containing the isopropylamine salt of glyphosate and a non-ionic tallow amine surfactant.
Glyphosate Poisoning
TLDR
Experimental studies suggest that the toxicity of the surfactant, polyoxyethyleneamine (POEA), is greater than theoxicity of glyphosate alone and commercial formulations alone and there is insufficient evidence to conclude that glyphosate preparations containing POEA are more toxic than those containing alternative surfactants.
Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans.
TLDR
It was concluded that the use of Roundup herbicide does not result in adverse effects on development, reproduction, or endocrine systems in humans and other mammals, and glyphosate is noncarcinogenic.
Glyphosate herbicide formulation: a potentially lethal ingestion.
TLDR
The deaths in this series are analysed in the context of a review of existing literature and a clinical guide to assessing severity of GlySH toxicity is proposed and treatment modalities discussed.
Determination of the herbicide glyphosate and its metabolite in biological specimens by gas chromatography-mass spectrometry. A case of poisoning by roundup herbicide.
TLDR
Using the gas chromatography-mass spectrometry (GC-MS) method of analysis, the presence of GLYP was identified in the full mass spectra obtained from the serum of a patient who may or may not have ingested Roundup.
Metabolism of glyphosate in Sprague-Dawley rats: tissue distribution, identification, and quantitation of glyphosate-derived materials following a single oral dose.
Effects of phenoxyherbicides and glyphosate on the hepatic and intestinal biotransformation activities in the rat.
TLDR
The results indicate that phenoxyacetic acids, especially MCPA, may have potent effects on the metabolism of xenobiotics and Glyphosate, not chemically related to Phenoxyacids, seems to inhibit monooxygenases.
Diagnosis and interpretation of steatosis and steatohepatitis.
TLDR
The morphological features of steatosis and steatohepatitis are described, their pathogenesis is considered, their clinical significance is outlined, and the clinical significance of the different patterns of injury is outlined.
...
...