Pathological and Physiological Factors Affecting Drug Absorption, Distribution, Elimination, and Response in Man

@inproceedings{Prescott1975PathologicalAP,
  title={Pathological and Physiological Factors Affecting Drug Absorption, Distribution, Elimination, and Response in Man},
  author={Laurence Prescott},
  year={1975}
}
Although drugs are used primarily for the treatment of disease, surprisingly little is known of the way in which disease states or physiological factors modify drug action in man. In contrast, extensive studies in laboratory animals have shown that these factors can have striking effects which if applied to man would have enormous clinical significance. The failure to apply this basic knowledge to clinical medicine amounts virtually to negligence on the part of the medical profession. 

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