Pathological abnormalities in the normal-appearing white matter in multiple sclerosis

@article{Allen2001PathologicalAI,
  title={Pathological abnormalities in the normal-appearing white matter in multiple sclerosis},
  author={Ingrid V. Allen and Stephen McQuaid and Meenakshi Mirakhur and G. Nevin},
  journal={Neurological Sciences},
  year={2001},
  volume={22},
  pages={141-144}
}
In established cases of multiple sclerosis (MS), the normal-appearing white matter (NAWM), as defined for magnetic resonance imaging (MRI), is abnormal in the majority of cases. The clinical significance of these NAWM abnormalities is the subject of debate, but there is strong correlation with degree and progression of disability. New lesions form in NAWM before blood-brain barrier breakdown, as evidenced by gadolinium enhancement. The pathological basis of these neuroimaging abnormalities is… CONTINUE READING