Pathological abnormalities in the normal-appearing white matter in multiple sclerosis

  title={Pathological abnormalities in the normal-appearing white matter in multiple sclerosis},
  author={Ingrid V. Allen and Stephen McQuaid and Meenakshi Mirakhur and G. B. Nevin},
  journal={Neurological Sciences},
Abstract. In established cases of multiple sclerosis (MS), the normal-appearing white matter (NAWM), as defined for magnetic resonance imaging (MRI), is abnormal in the majority of cases. The clinical significance of these NAWM abnormalities is the subject of debate, but there is strong correlation with degree and progression of disability. New lesions form in NAWM before blood-brain barrier breakdown, as evidenced by gadolinium enhancement. The pathological basis of these neuroimaging… 

Gray and normal-appearing white matter in multiple sclerosis: an MRI perspective

It is proposed that more spatially specific investigations, ideally utilizing subject-specific anatomical information from, for example, diffusion fiber-tracking techniques, could be used to gain more insight into the relations between normal-appearing white matter changes, cortical changes, magnetic resonance visible focal-lesions, and physical and cognitive deficits.

Diffusely abnormal white matter in chronic multiple sclerosis: imaging and histopathologic analysis.

This study classifies DAWM in chronic MS as an abnormality that is different from normal-appearing WM and focal WM lesions, most likely resulting from the cumulative effects of ongoing inflammation and axonal pathology.

Preactive lesions in multiple sclerosis

Preactive lesions in MS represent early stages in the formation of destructive MS lesions, characterized by clusters of activated microglia in otherwise normal-appearing white matter, which are expected to hold important clues to stop the inflammatory process in MS.

Normal Appearing and Diffusely Abnormal White Matter in Patients with Multiple Sclerosis Assessed with Quantitative MR

Changes in NAWM and DAWM are independent pathological entities in the disease and the correlation between qMRI and clinical status may shed new light on the clinicoradiological paradox.

Neuropathologic Correlates of Magnetic Resonance Imaging in Multiple Sclerosis

  • G. MooreC. Laule
  • Medicine, Psychology
    Journal of neuropathology and experimental neurology
  • 2012
Technical considerations in MRI-pathology correlativestudies are outlined and the past and current status of the ability to correlate focal and diffuse changes on the MRI with neuropathologic findings in MS patients are described.

MRI Analysis to Detect Gray Matter Tissue Loss in Multiple Sclerosis

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Pathology of the Normal-Appearing White Matter in Multiple Sclerosis

Loss of axons seems to be the major determinant of the persistent neurological deficit in the progressive disease stage of MS patients, which may be either primary or secondary.

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3T magnetic resonance imaging of cortical grey matter lesions in Multiple Sclerosis

This project investigated the role of phase sensitive inversion recovery (PSIR), a T1-weighted MRI sequence, using a 3T MRI scanner, for the detection of CGM lesions in multiple sclerosis and systematically investigated if the use of high resolution PSIR scans can improve CGM lesion detection and classification, when compared to DIR.

White Matter Damage in Multiple Sclerosis

Current knowledge on the interrelation between the processes of inflammation, neurodegeneration and demyelination that occurs in MS is summarized and the mechanisms that may be involved in the damage of the different cellular components of white matter are analyzed.



A histological, histochemical and biochemical study of the macroscopically normal white matter in multiple sclerosis

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Transected axons are common in the lesions of multiple sclerosis, and axonal transection may be the pathologic correlate of the irreversible neurologic impairment in this disease.

Axonal damage in acute multiple sclerosis lesions.

The results show the expression of amyloid precursor protein in damaged axons within acute multiple sclerosis lesions, and in the active borders of less acute lesions, which may have implications for the design and timing of therapeutic intervention.

Magnetization transfer changes in the normal appering white matter precede the appearance of enhancing lesions in patients with multiple sclerosis

It is suggested that changes in the NAWM of patients with MS occur before lesions becomes evident on conventional MRI scans.

Blood-brain barrier damage in acute multiple sclerosis plaques. An immunocytological study.

The results suggest that the inflammatory changes in early MS plaques may have some specificity which could be related to the antigens whose presence is inferred by the colocation of complement and immunoglobulin on material within activated macrophages and astrocytes.

Remyelination in multiple sclerosis

Stimulation of remyelination in multiple sclerosis lesions may be one possible therapeutic approach. However, since the pathology and pathogenesis of multiple sclerosis may be heterogeneous, it is

Spinal cord axonal loss in multiple sclerosis: a post‐mortem study

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Corpus callosum in multiple sclerosis

  • R. BarnardM. Triggs
  • Medicine, Psychology
    Journal of neurology, neurosurgery, and psychiatry
  • 1974
The ventricular enlargement noted in this series could not be explained either on the basis of obstruction to the flow of cerebrospinal fluid, or by the effects of shrinkage of the white matter.

Immunocytochemical observations on the distribution of myelin‐associated glycoprotein and myelin basic protein in multiple sclerosis lesions

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Macrophages in multiple sclerosis.