Pathological Tau Disrupts Ongoing Network Activity

@article{MenkesCaspi2015PathologicalTD,
  title={Pathological Tau Disrupts Ongoing Network Activity},
  author={Noa Menkes-Caspi and Hagar G. Yamin and Vered Kellner and Tara L Spires-Jones and Dana Cohen and Edward Stern},
  journal={Neuron},
  year={2015},
  volume={85},
  pages={959-966}
}
Pathological tau leads to dementia and neurodegeneration in tauopathies, including Alzheimer's disease. It has been shown to disrupt cellular and synaptic functions, yet its effects on the function of the intact neocortical network remain unknown. Using in vivo intracellular and extracellular recordings, we measured ongoing activity of neocortical pyramidal cells during various arousal states in the rTg4510 mouse model of tauopathy, prior to significant cell death, when only a fraction of the… CONTINUE READING
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