Pathological Laughing and Crying

@article{Dark1996PathologicalLA,
  title={Pathological Laughing and Crying},
  author={Frances Dark and J J Mcgrath and Maria A. Ron},
  journal={Australian and New Zealand Journal of Psychiatry},
  year={1996},
  volume={30},
  pages={472 - 479}
}
  • F. Dark, J. Mcgrath, M. Ron
  • Published 1 August 1996
  • Psychology, Medicine
  • Australian and New Zealand Journal of Psychiatry
Objective: To review the clinical features, neurobiological correlates and treatment of pathological laughing and crying. Method: Selective literature review. Results: Attacks of involuntary, irresistible laughing or crying have long been recognised as sequelae of brain damage. There is controversy about the clinical features of these attacks, the stimuli that provoke them and their relation to affective disorder. The pathophysiology of pathological laughing and crying is still unclear. It can… 

Duloxetine for pathological laughing and crying.

TLDR
An important first step in the recognition and accurate measurement of PLC has been accomplished with the introduction of specific rating scales, such as the interviewer administered Pathological Laughter and Crying Scale validated for use with stroke victims.

Pathological Laughter and Crying

TLDR
The pathophysiology and various treatment approaches available for pathological laughing and crying are described, with varying levels of treatment success.

Pathological laughing and crying in amyotrophic lateral sclerosis is related to frontal cortex function

TLDR
Physiological reactions as well as behavioural changes suggest that this phenomenon is primarily an expression of reduced inhibitory activity of the frontal cortex, since frontal dysfunction could explain changes in physiological parameters in the patient group.

Treatment of pathologic laughing and crying

TLDR
Patients with PLC must not be misunderstood as “depressed” or “manic” solely on the basis of their frequent episodic crying or laughing, and selective serotonin reuptake inhibitors (SSRIs) are recommended as first-line treatments for this condition.

Understanding Excessive Crying in Neurologic Disorders: Nature, Pathophysiology, Assessment, Consequences, and Treatment

TLDR
This review provides an overview of the literature on excessive crying in neurologic disorders and recommends choosing one term for the phenomenon of EC that does justice to the fact that the threshold for such crying is exceptionally low.

Pathological laughing and crying in multiple sclerosis: a preliminary report suggesting a role for the prefrontal cortex

As part of a wide ranging study investigating the prevalence, demographic and disease related characteristics of pathological laughing and crying (PLC) in multiple sclerosis (MS), a putative role for

Review of pseudobulbar affect including a novel and potential therapy.

  • R. SchifferL. Pope
  • Psychology, Medicine
    The Journal of neuropsychiatry and clinical neurosciences
  • 2005
TLDR
Evidence suggests that treatment with a fixed combination of dextromethorphan and the cytochrome P450 2D6 enzyme inhibitor, quinidine, can improve PBA.

Alternative cognitive therapy for emotional instability (pathologic laughing and crying).

  • A. Kasprisin
  • Psychology, Biology
    Physical medicine and rehabilitation clinics of North America
  • 2004

Crying and health: Popular and scientific conceptions

TLDR
It is concluded that the question regarding whether crying brings relief has yielded seemingly contrasting findings, dependent on the design of the study, and more systematic and well-designed studies are needed to clarify the relationship between crying and health.
...

References

SHOWING 1-10 OF 47 REFERENCES

PATHOLOGIC LAUGHING AND CRYING

TLDR
These affective responses appear in case of cerebrovascular disease at the same time as, or soon after, the ictus, in which pathologic laughing and crying commonly occur.

Pathological laughing and crying following stroke: validation of a measurement scale and a double-blind treatment study.

TLDR
The severity of symptoms in pathological emotional display can be reliably quantified with the Pathological Laughter and Crying Scale, and treatment with nortriptyline can effectively ameliorate this emotional disorder.

Treatment of pathologic laughing and weeping with amitriptyline.

TLDR
It is concluded that amitriptyline is effective in the treatment of this disturbance of affective expression, and that this effect is distinct from the antidepressant effect of the medication.

Pathologic laughter and crying in ALS: a search for their origin

TLDR
A study was made of the incidence of pathologic laughter and crying in patients whose motor neuron disease had started before the age of 45 years, finding the youngest patient with spells was 31 when his illness began and 35 when he started to have bouts of crying.

Pathological Laughter: A Review of the Literature

  • D. Black
  • Psychology, Biology
    The Journal of nervous and mental disease
  • 1982
TLDR
Normal laughter is a unique human behavior with characteristic facial and respiratory patterns elicited by a variety of stimulus conditions, but pathological laughter occurs when laughter is inappropriate, unrestrained, uncontrollable, or dissociated from any stimulus.

Is the syndrome of pathological laughing and crying a manifestation of pseudobulbar palsy?

TLDR
The authors' data suggest that pathological laughing and crying can occur without any other manifestation of pseudobulbar palsy.

Pathologic laughing and crying treated with levodopa.

TLDR
Because part of pathologic laughing and crying seems to be caused by the decreased function of the dopaminergic neuron, levodopa or amantadine is worth trying.

Pathological Display of Affect in Patients with Depression and Right Frontal Brain Damage: An Alternative Mechanism

TLDR
The cases argue that two organic brain diseases—one structural and the other “physiopharmacological”—may interact to produce pathological display of affect that cannot be accounted for by traditional neurological explanations, and suggest that pathological affect is a valuable clinical indicator of an underlying major depression in some brain-injured patients.

Mirth, laughter and gelastic seizures.

TLDR
Three patients with gelastic seizures and laughter elicited by electrical stimulation of the cortex are presented who provide some insight into the mechanisms of laughter and its emotional concomitants, revealing a high likelihood of cingulate and basal temporal cortex contribution to laughter and mirth in humans.