Pathological Findings of a Subependymal Giant Cell Astrocytoma Following Treatment With Rapamycin.

@article{Cheng2015PathologicalFO,
  title={Pathological Findings of a Subependymal Giant Cell Astrocytoma Following Treatment With Rapamycin.},
  author={Sylvia H. Cheng and Cynthia E. Hawkins and Michael D. Taylor and Ute Katharina Bartels},
  journal={Pediatric neurology},
  year={2015},
  volume={53 3},
  pages={238-242.e1}
}
BACKGROUND Tuberous sclerosis complex is a heritable multisystem disorder associated with genes involved in the formation of a tumor-suppressor complex acting through the Ras homologue enriched in brain protein to limit activation of the mammalian target of rapamycin complex I. Mutations in these genes result in enhanced mammalian target of rapamycin signaling and may cause neurological manifestations including brain tubers, subependymal nodules, and subependymal giant cell astrocytomas. These… CONTINUE READING
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