Pathological Display of Affect in Patients with Depression and Right Frontal Brain Damage: An Alternative Mechanism

@article{Ross1987PathologicalDO,
  title={Pathological Display of Affect in Patients with Depression and Right Frontal Brain Damage: An Alternative Mechanism},
  author={Elliott D. Ross and Rege S. Stewart},
  journal={The Journal of Nervous and Mental Disease},
  year={1987},
  volume={175},
  pages={165-172}
}
  • E. Ross, R. S. Stewart
  • Published 1 March 1987
  • Psychology, Medicine, Biology
  • The Journal of Nervous and Mental Disease
Two patients are reported with the acute onset of pathological crying following right inferior frontal brain damage. Both had severe endogenous depession and neither had pseudobulbar palsy. These and other cases argue that two organic brain diseases—one structural and the other “physiopharmacological”—may interact to produce pathological display of affect that cannot be accounted for by traditional neurological explanations. A pharmacological mechanism for the rapid amelioration of pathological… 

Psychiatry and the Frontal Lobes

TLDR
The frontal lobes of the brain have long been regarded as enigmatic in their function and perhaps should be considered even more so in states of dysfunction, and those psychiatric conditions where an aetiological role for frontal lobe dysfunction has been proposed are discussed.

Cerebral Imaging and Emotional Correlates

TLDR
Emotional changes associated with cerebral damage are common and may range from depression to hypomania or complete denial of illness and also may result as a direct consequence of damage to the brain.

The neuropathologic basis of major affective disorders: neuroanatomic insights.

  • B. GuzeM. Gitlin
  • Psychology, Medicine
    The Journal of neuropsychiatry and clinical neurosciences
  • 1994
TLDR
Both structural and functional brain imaging suggest specific regions where abnormalities are associated with mood disorders, and data that emerge from these sources implicate the basal ganglia, frontal cortex, and temporal lobes in the production of mood disorder symptoms.

"No longer Gage": frontal lobe dysfunction and emotional changes.

TLDR
It is concluded that symptoms of frontal lobe damage that have been labeled as emotional disturbances may be classified as disorders of drive or motivation, mood (subjective emotional experience), and affect (emotional expression).

Alternative cognitive therapy for emotional instability (pathologic laughing and crying).

  • A. Kasprisin
  • Psychology, Biology
    Physical medicine and rehabilitation clinics of North America
  • 2004

Assessment of depression in patients with brain pathology: the case of stroke.

TLDR
The authors examine the challenges to depression assessment in patients who have had a stroke, the neurologically impaired population in which it has been most frequently studied and offer suggestions for improving the specificity, consistency, validity, and reliability of assessment methods and procedures.

Pathological laughing and crying in multiple sclerosis: a preliminary report suggesting a role for the prefrontal cortex

As part of a wide ranging study investigating the prevalence, demographic and disease related characteristics of pathological laughing and crying (PLC) in multiple sclerosis (MS), a putative role for

Depressive symptoms following stroke.

TLDR
The hypothesis that lesion location is a valid and significant factor in the mixture of influences which may result in a dysphoric mood state following stroke is supported.

Degenerative prefrontal damage in a young adult: Static and dynamic imaging and Neuropsychological Correlates

TLDR
Frontal lobe degeneration was examined with magnetic resonance imaging and (1 8F)2-fluoro-2-deoxy—glucose positron-emission tomography, and was found to include both orbital and dorsolateral aspects of the frontal lobes.

Affective-prosodic deficits in schizophrenia: profiles of patients with brain damage and comparison with relation to schizophrenic symptoms

TLDR
The profile of affective-prosodic deficits found in impaired schizophrenic patients is characteristic of RBD, supporting the concept that schizophrenia is a bihemispheric disease process.
...