Pathological Basis of Gastroesophageal Reflux Disease

  title={Pathological Basis of Gastroesophageal Reflux Disease},
  author={Parakrama T. Chandrasoma},
  journal={World Journal of Surgery},
Many of the present definitions of Barrett’s esophagus are based on the dogma that 2 to 3 cm of cardiac mucosa normally line the distal esophagus and proximal stomach. Recent autopsy data refute this dogma. Cardiac mucosa has been shown to be frequently absent from the squamocolumnar junctional zone. When present, its extent is less than 0.5 cm in almost all children and most adults. Cardiac mucosal length increases with age. Patients who have cardiac mucosa are significantly more likely to… CONTINUE READING


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