Pathologic thrombopoiesis of rheumatoid arthritis

  title={Pathologic thrombopoiesis of rheumatoid arthritis},
  author={Ihsan Ertenli and Sedat Kiraz and Mehmet Akif {\"O}zt{\"u}rk and Ibrahim Celalettin Haznedaroğlu and I. Celik and Meral Çalg{\"u}neri},
  journal={Rheumatology International},
Rheumatoid arthritis (RA) is frequently complicated by thrombocytosis correlated with disease activity. The exact pathogenetic mechanism(s) that cause increased platelet counts in RA are still unknown. Recent investigations indicate that proinflammatory pleiotropic cytokines of RA also have megakaryocytopoietic/thrombopoietic properties. Moreover, several lineage-dominant hematopoietic cytokines can also act as acute phase responders and contribute to the inflammation. This review focuses on… CONTINUE READING


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