Pathologic endoplasmic reticulum stress induced by glucotoxic insults inhibits adipocyte differentiation and induces an inflammatory phenotype.

@article{Longo2016PathologicER,
  title={Pathologic endoplasmic reticulum stress induced by glucotoxic insults inhibits adipocyte differentiation and induces an inflammatory phenotype.},
  author={Michele Longo and Rosa Spinelli and Vittoria D'esposito and Federica Zatterale and Francesca Fiory and Cecilia Nigro and Gregory Alexander Raciti and Claudia Miele and Pietro Formisano and Francesco Beguinot and Bruno di Jeso},
  journal={Biochimica et biophysica acta},
  year={2016},
  volume={1863 6 Pt A},
  pages={
          1146-56
        }
}
Adipocyte differentiation is critical in obesity. By controlling new adipocyte recruitment, adipogenesis contrasts adipocyte hypertrophy and its adverse consequences, such as insulin resistance. Contrasting data are present in literature on the effect of endoplasmic reticulum (ER) stress and subsequent unfolded protein response (UPR) on adipocyte differentiation, being reported to be either necessary or inhibitory. In this study, we sought to clarify the effect of ER stress and UPR on adipocyte… Expand
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