Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis.

@article{Jenkins2007PathologicCO,
  title={Pathologic consequences of STAT3 hyperactivation by IL-6 and IL-11 during hematopoiesis and lymphopoiesis.},
  author={Brendan J Jenkins and Andrew W Roberts and Claire J. Greenhill and Meri Najdovska and Ther{\'e}se Lundgren-May and Lorraine Robb and Dianne Grail and Matthias Ernst},
  journal={Blood},
  year={2007},
  volume={109 6},
  pages={2380-8}
}
We have previously demonstrated that STAT3 hyperactivation via the interleukin 6 (IL-6) cytokine family receptor gp130 in gp130 (Y757F/Y757F) mice leads to numerous hematopoietic and lymphoid pathologies, including neutrophilia, thrombocytosis, splenomegaly, and lymphadenopathy. Because IL-6 and IL-11 both signal via a gp130 homodimer, we report here a genetic approach to dissect their individual roles in these pathologies. Neutrophilia and thrombocytosis were absent in gp130 (Y757F/Y757F) mice… CONTINUE READING