Pathologic conformations of prion proteins.

  title={Pathologic conformations of prion proteins.},
  author={Fred E. Cohen and Stanley B Prusiner},
  journal={Annual review of biochemistry},
While many aspects of prion disease biology are unorthodox, perhaps the most fundamental paradox is posed by the coexistence of inherited, sporadic, and infectious forms of these diseases. Sensible molecular mechanisms for prion propagation must explain all three forms of prion diseases in a manner that is compatible with the formidable array of experimental data derived from histopathological, biochemical, biophysical, human genetic, and transgenetic studies. In this review, we explore prion… CONTINUE READING

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