Pathologic changes in the long-term transplanted heart: A morphometric study of myocardial hypertrophy, vascularity, and fibrosis☆

@article{Rowan1990PathologicCI,
  title={Pathologic changes in the long-term transplanted heart: A morphometric study of myocardial hypertrophy, vascularity, and fibrosis☆},
  author={Reed A Rowan and Margaret E. Billingham},
  journal={Human pathology},
  year={1990},
  volume={21 7},
  pages={767-72}
}
Myocyte hypertrophy and myocardial fibrosis have been observed in transplanted human hearts, and both could potentially have an adverse effect on long-term cardiac function. There has been some concern that distant donor heart procurement and cyclosporine treatment increase the risk of these changes, but their incidence and severity have not been documented quantitatively in large numbers of cardiac transplant recipients. We used light microscopic morphometric methods to estimate myocardial… CONTINUE READING

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