Pathologic changes in murine leishmaniasis (Leishmania donovani) with special reference to the dynamics of granuloma formation in the liver.

@article{Gutierrez1984PathologicCI,
  title={Pathologic changes in murine leishmaniasis (Leishmania donovani) with special reference to the dynamics of granuloma formation in the liver.},
  author={Yunin Gutierrez and John A. Maksem and Neil E. Reiner},
  journal={The American journal of pathology},
  year={1984},
  volume={114 2},
  pages={222-30}
}
The histopathologic changes in liver, spleen, and bone marrow of BALB/c mice infected for 6 months with Leishmania donovani are described. Granulomas were the most important histologic lesions found; and the dynamics of their formation, collagen deposition, and resolution in the liver were studied. The number of hepatic granulomas increased until the eighth week and then decreased steadily. In contrast to the liver granulomas, those of spleen and bone marrow do not mature or show collagen… CONTINUE READING