Pathologic axons and synapses in human neuropsychiatric disorders.

  title={Pathologic axons and synapses in human neuropsychiatric disorders.},
  author={Nicholas K. Gonatas and Adyr Moss},
  journal={Human pathology},
  volume={6 5},
Ultrastructural studies of cerebral biopsy specimens from patients with various forms of psychomotor retardation and dementia have disclosed pathologic changes in axons and presynaptic or postsynaptic processes. The clinical disorders with lesions in axons and presynaptic terminals are reviewed. Three basic abnormalities have been detected: proliferation of tubulovesicular structures which probably originate from the smooth endoplasmic reticulum, "abnormal" mitochondria, and proliferation of 80… CONTINUE READING