Pathologic Features and Clinical Significance of “Backwash” Ileitis in Ulcerative Colitis

@article{Haskell2005PathologicFA,
  title={Pathologic Features and Clinical Significance of “Backwash” Ileitis in Ulcerative Colitis},
  author={Henry L. Haskell and Charles W. Andrews and Sarathchandra I. Reddy and Kleanthis G. Dendrinos and Francis A. Farraye and Arthur F. Stucchi and James M. Becker and Robert D Odze},
  journal={The American Journal of Surgical Pathology},
  year={2005},
  volume={29},
  pages={1472-1481}
}
Patients with ulcerative colitis (UC) may develop inflammation in the distal ileum thought to be due to “backwash” of cecal contents (“backwash ileitis”). However, a systematic analysis of ileal changes in UC has never been performed, and the prevalence and criteria for “backwash” ileitis have not been defined. The aim of this study was to evaluate the prevalence and spectrum of inflammatory changes in the ileum in patients with UC and to correlate ileal changes with outcome after total… Expand
Microscopic / "Backwash" Ileitis and its Association with Colonic Disease in New Onset Pediatric Ulcerative Colitis.
TLDR
Patients with new onset ulcerative colitis may have microscopic ileal inflammation at time of diagnosis, even if the terminal ileum appears macroscopically normal, and children with microscopic ilesitis in the context of UC do not need to be reclassified as "indeterminate colitis" or Crohn's disease. Expand
Histological features of ileitis differentiating pediatric Crohn disease from ulcerative colitis with backwash ileitis.
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  • Medicine
  • Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
  • 2018
TLDR
Combining histological features of ileitis and clinical variables can adequately discriminate between the presence and absence of Crohn disease in children who present with confluent colitis and ilesitis when newly diagnosed with inflammatory bowel disease (IBD). Expand
Contemporary morphologic definition of backwash ileitis in ulcerative colitis and features that distinguish it from Crohn disease.
TLDR
Terminal ileum (TI) sections from 250 ulcerative colitis (UC) total colectomy specimens resected during 3 periods and endoscopic TI biopsy specimens from 100 contemporary chronic UC and 100 Crohn disease patients were reviewed, finding the activity level of BWI correlated with level of cecal UC. Expand
Mucosal inflammation in the terminal ileum of ulcerative colitis patients: endoscopic findings and cytokine profiles.
TLDR
Elevated ileal cytokines might reflect a reaction to regurgitation of colonic content into the ileum, but in patients without backwash ileitis, alternative factors are expected to contribute to the aetiology of ILEal inflammation. Expand
Backwash ileitis does not affect pouch outcome in patients with ulcerative colitis with restorative proctocolectomy.
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  • Medicine
  • Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
  • 2011
TLDR
Ileal inflammation is not a contraindication for restorative proctocolectomy with ileal pouch construction in patients with UC or idiopathic inflammatory bowel disease of indeterminate type and pouch outcomes are not affected. Expand
Pathologic Features of Ulcerative Colitis in Patients With Primary Sclerosing Cholangitis: A Case-control Study
TLDR
UC patients with PSC show a propensity for more extensive, but less active, disease but are otherwise characterized by similar pathologic findings compared with UC patients without PSC. Expand
Backwash Is Hogwash: The Clinical Significance of Ileitis in Ulcerative Colitis
TLDR
Evidence is cited to propose that ileal infl ammation in UC may simply represent a primary manifestation of UC in that organ, for which the term “UC-associated ileitis” is proposed. Expand
Ileal Perforation in a Patient with Ulcerative Colitis after Proctocolectomy
TLDR
A 66-year-old male with UC who presented with ileal perforation eight days after proctocolectomy is reported, indicating that backwash ileitis or diffuse enteritis is the most probable diagnosis in this case. Expand
Prospective Evaluation of Terminal Ileitis in a Surveillance Population of Patients with Ulcerative Colitis
TLDR
Ileitis in Patients with UC may represent a primary extracolonic manifestation of UC in patients with inactive or mild disease and is not due to backwash. Expand
Backwash ileitis in ulcerative colitis: Are there MR enterographic features that distinguish it from Crohn disease?
TLDR
In patients with definite diagnosis of UC, ileocecal valve gaping and terminal ileum dilatation suggest the development of BWI, but these findings cannot be use to differentiate cause of terminal ilesitis in patients with unconfirmed diagnosis and do not give reliable information about the causative factor of ileitis. Expand
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References

SHOWING 1-10 OF 48 REFERENCES
Diffuse Duodenitis Associated With Ulcerative Colitis
TLDR
Patients with pancolitis and DD do not necessarily have CD, but rather may have UC and, most importantly, that successful ERPT procedures may be performed in these patients. Expand
Histologic Predictors of Pouchitis in Patients with Chronic Ulcerative Colitis
TLDR
There are several histologic features in colectomy specimens from UC patients who have undergone an IPAA procedure that may help predict the subsequent development of pouchitis, and appendiceal ulceration is highly associated with pouchitis. Expand
Backwash ileitis is strongly associated with colorectal carcinoma in ulcerative colitis.
TLDR
There is a strong association of backwash ileitis with CRC in patients with ulcerative colitis who undergo proctocolectomy, and primary sclerosing cholangitis was strongly associated with backwash  ileitis. Expand
Pouchitis and extraintestinal manifestations of inflammatory bowel disease after ileal pouch-anal anastomosis.
TLDR
It is concluded that pouchitis occurred frequently after IPAA and that patients with EIMs were at higher risk of developing pouchitis than were patients who never had EIM s and that some patients experienced a temporal relationship between flares of E IMs and pouchitis. Expand
Ulcerative colitus and Crohn's disease of the colon - a comparison of the long term postoperative courses.
TLDR
Differences in the clinical courses of UC and CDC after colectomy and ileostomy are of degree and do not reflect the ultimate course or potential for rehabilitation, and decisions regarding surgical therapy should be made independent of the diagnosis of UC or CDC. Expand
Is Ileoscopy With Biopsy Worthwhile in Patients Presenting With Symptoms of Inflammatory Bowel Disease?
TLDR
Ileoscopy with biopsy is useful in carefully selected patients presenting with symptoms of inflammatory bowel disease, and main indications are diagnosis of isolated ileal disease in the presence of a normal colon and differential diagnosis in patients with pancolitis and predominantly left-sided colitis. Expand
Preoperative terminal ileal and colonic resection histopathology predicts risk of pouchitis in patients after ileoanal pull-through procedure.
TLDR
Preoperative terminal ileal and colonic histopathology predicts active inflammation of pouches after IAPT, and patients who are preoperatively assessed to have extensive disease of the colon, ILEal disease, or both appear to be at greater risk for the development of pouchitis after I APT. Expand
Prospective evaluation of early morphological changes in pelvic ileal pouches.
TLDR
Pelvic ileal pouches develop inflammatory, phenotypic, and kinetic changes early in the course of function but have only a limited potential for colonic type metaplasia. Expand
Pathology of indeterminate colitis.
  • R. Odze
  • Medicine
  • Journal of clinical gastroenterology
  • 2004
TLDR
The natural history of IC more closely resembles that of UC than CD, supporting the notion that most patients with IC probably have UC and can safely undergo an ileal pouch-anal anastomosis procedure and have a reasonably good chance of having a good outcome. Expand
Relationship of backwash ileitis to ileal pouchitis after ileal pouch-anal anastomosis
TLDR
It is concluded that the presence of backwash ileitis does not predispose to later development of pouchitis, and so does not contraindicate use of the inflammed terminal ileum for construction of the ileal pouch and anastomosis. Expand
...
1
2
3
4
5
...