Pathogens use structural mimicry of native host ligands as a mechanism for host receptor engagement.

Abstract

A pathogen's ability to engage host receptors is a critical determinant of its host range and interspecies transmissibility, key issues for understanding emerging diseases. However, the identification of host receptors, which are also attractive drug targets, remains a major challenge. Our structural bioinformatics studies reveal that both bacterial and… (More)
DOI: 10.1016/j.chom.2013.05.005

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Citation Velocity: 9

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