Pathogens target DC-SIGN to influence their fate DC-SIGN functions as a pathogen receptor with broad specificity.

@article{Geijtenbeek2003PathogensTD,
  title={Pathogens target DC-SIGN to influence their fate DC-SIGN functions as a pathogen receptor with broad specificity.},
  author={Teunis B H Geijtenbeek and Yvette van Kooyk},
  journal={APMIS : acta pathologica, microbiologica, et immunologica Scandinavica},
  year={2003},
  volume={111 7-8},
  pages={698-714}
}
Dendritic cells (DC) are vital in the defense against pathogens. To sense pathogens DC express pathogen recognition receptors such as toll-like receptors (TLR) and C-type lectins that recognize different fragments of pathogens, and subsequently activate or present pathogen fragments to T cells. It is now becoming evident that some pathogens subvert DC functions to escape immune surveillance. HIV-1 targets the DC-specific C-type lectin DC-SIGN to hijack DC for viral dissemination. HIV-1 binding… CONTINUE READING

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