Pathogenomic Inference of Virulence-Associated Genes in Leptospira interrogans

@inproceedings{Lehmann2013PathogenomicIO,
  title={Pathogenomic Inference of Virulence-Associated Genes in Leptospira interrogans},
  author={Jason S. Lehmann and Derrick E. Fouts and Daniel H. Haft and Anthony P. Cannella and Jessica N. Ricaldi and Lauren M. Brinkac and Derek M. Harkins and Scott A. Durkin and Ravi K. Sanka and Granger Sutton and Angelo C Moreno and Joseph M Vinetz and Michael A. Matthias},
  booktitle={PLoS neglected tropical diseases},
  year={2013}
}
Leptospirosis is a globally important, neglected zoonotic infection caused by spirochetes of the genus Leptospira. Since genetic transformation remains technically limited for pathogenic Leptospira, a systems biology pathogenomic approach was used to infer leptospiral virulence genes by whole genome comparison of culture-attenuated Leptospira interrogans serovar Lai with its virulent, isogenic parent. Among the 11 pathogen-specific protein-coding genes in which non-synonymous mutations were… CONTINUE READING
Highly Cited
This paper has 34 citations. REVIEW CITATIONS
Recent Discussions
This paper has been referenced on Twitter 8 times over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 61 references

Similar Papers

Loading similar papers…