Pathogenomic Inference of Virulence-Associated Genes in Leptospira interrogans

  title={Pathogenomic Inference of Virulence-Associated Genes in Leptospira interrogans},
  author={Jason S. Lehmann and Derrick E. Fouts and Daniel H. Haft and Anthony P. Cannella and Jessica N. Ricaldi and Lauren M. Brinkac and Derek M. Harkins and Scott A. Durkin and Ravi K. Sanka and Granger Sutton and Angelo C Moreno and Joseph M Vinetz and Michael A. Matthias},
  booktitle={PLoS neglected tropical diseases},
Leptospirosis is a globally important, neglected zoonotic infection caused by spirochetes of the genus Leptospira. Since genetic transformation remains technically limited for pathogenic Leptospira, a systems biology pathogenomic approach was used to infer leptospiral virulence genes by whole genome comparison of culture-attenuated Leptospira interrogans serovar Lai with its virulent, isogenic parent. Among the 11 pathogen-specific protein-coding genes in which non-synonymous mutations were… CONTINUE READING
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