Pathogenicity of influenza A/Seal/Mass/1/80 virus mutants for mammalian species

@article{Scheiblauer1995PathogenicityOI,
  title={Pathogenicity of influenza A/Seal/Mass/1/80 virus mutants for mammalian species},
  author={H. Scheiblauer and Alan P. Kendal and Rudolf Rott},
  journal={Archives of Virology},
  year={1995},
  volume={140},
  pages={341-348}
}
Increases in infectiousness, neurotropism and virulence were found in a laboratory variant of influenza A/Seal/Massachussets/1/80 (H7N7) virus having a highly cleavable hemagglutinin. Sequential passage from host to host further increased pathogenicity of the H7N7 virus in mice, ferrets and rats.