Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma

  title={Pathogenicity of a disease-associated human IL-4 receptor allele in experimental asthma},
  author={Raffi Tachdjian and Clinton B Mathias and Shadi Al Khatib and P J Bryce and Hong Sook Kim and Frank Blaeser and Brian D. O'Connor and Danuta M. Rzymkiewicz and Andrew H. Chen and Michael J Holtzman and Gurjit K. Khurana Hershey and Holger Garn and Hani Harb and Harald Renz and Hans C. Oettgen and Talal A Chatila},
  booktitle={The Journal of experimental medicine},
Polymorphisms in the interleukin-4 receptor alpha chain (IL-4R alpha) have been linked to asthma incidence and severity, but a causal relationship has remained uncertain. In particular, a glutamine to arginine substitution at position 576 (Q576R) of IL-4R alpha has been associated with severe asthma, especially in African Americans. We show that mice carrying the Q576R polymorphism exhibited intense allergen-induced airway inflammation and remodeling. The Q576R polymorphism did not affect… CONTINUE READING
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