Pathogenicity of Misfolded and Dimeric HLA-B27 Molecules

  title={Pathogenicity of Misfolded and Dimeric HLA-B27 Molecules},
  author={Antony Nicodemus Antoniou and Izabela Lenart and David B. Guiliano},
  booktitle={International journal of rheumatology},
The association between HLA-B27 and the group of autoimmune inflammatory arthritic diseases, the spondyloarthropathies (SpAs) which include ankylosing spondylitis (AS) and Reactive Arthritis (ReA), has been well established and remains the strongest association between any HLA molecule and autoimmune disease. The mechanism behind this striking association remains elusive; however animal model and biochemical data suggest that HLA-B27 misfolding may be key to understanding its association with… CONTINUE READING
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