Pathogenicity islands of virulent bacteria: structure, function and impact on microbial evolution.

@article{Hacker1997PathogenicityIO,
  title={Pathogenicity islands of virulent bacteria: structure, function and impact on microbial evolution.},
  author={Joerg Hacker and Gabriele Blum-Oehler and Inge Muehldorfer and Helmut Tsch{\"a}pe},
  journal={Molecular microbiology},
  year={1997},
  volume={23 6},
  pages={1089-97}
}
Virulence genes of pathogenic bacteria, which code for toxins, adhesins, invasins or other virulence factors, may be located on transmissible genetic elements such as transposons, plasmids or bacteriophages. In addition, such genes may be part of particular regions on the bacterial chromosomes, termed 'pathogenicity islands' (Pais). Pathogenicity islands are found in Gram-negative as well as in Gram-positive bacteria. They are present in the genome of pathogenic strains of a given species but… CONTINUE READING
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