Pathogenicity islands and phages in Vibrio cholerae evolution.

  title={Pathogenicity islands and phages in Vibrio cholerae evolution.},
  author={Shah M. Faruque and John J Mekalanos},
  journal={Trends in microbiology},
  volume={11 11},
The identification of accessory genetic elements (plasmids, phages and chromosomal 'pathogenicity islands') encoding virulence-associated genes has facilitated our efforts to understand the origination of pathogenic microorganisms. Toxigenic Vibrio cholerae, the etiologic agent of cholera, represents a paradigm for this process in that this organism evolved from environmental nonpathogenic V. cholerae by acquisition of virulence genes. The major virulence genes in V. cholerae, which are… CONTINUE READING

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