Pathogenicity, attenuation, and immunogenicity of infectious bursal disease virus.

@article{Hassan1996PathogenicityAA,
  title={Pathogenicity, attenuation, and immunogenicity of infectious bursal disease virus.},
  author={Mohamed K. Hassan and Mohammad Q. Al-Natour and Lucy A. Ward and Yehia Mo Saif},
  journal={Avian diseases},
  year={1996},
  volume={40 3},
  pages={567-71}
}
An investigation was conducted in specific-pathogen-free chickens on the pathogenicity of bursa-derived and tissue culture-attenuated classic (STC) and variant (IN) serotype 1 strains of infectious bursal disease virus. The IN bursa-derived virus caused bursal inflammation, necrosis, and atrophy earlier than the bursa-derived STC virus. Both viruses lost their pathogenicity after four passages in BGM-70 cells. A statistically significant level (P < 0.05) of protection was observed in SPF… CONTINUE READING