Pathogenic shifts in endogenous microbiota impede tissue regeneration via distinct activation of TAK1/MKK/p38

@inproceedings{Arnold2016PathogenicSI,
  title={Pathogenic shifts in endogenous microbiota impede tissue regeneration via distinct activation of TAK1/MKK/p38},
  author={Christopher P Arnold and M Shane Merryman and Aleishia Harris-Arnold and Sean A. McKinney and Chris W. Seidel and Sydney Loethen and Kylie N Proctor and Longhua Guo and Alejandro S{\'a}nchez Alvarado},
  booktitle={eLife},
  year={2016}
}
The interrelationship between endogenous microbiota, the immune system, and tissue regeneration is an area of intense research due to its potential therapeutic applications. We investigated this relationship in Schmidtea mediterranea, a model organism capable of regenerating any and all of its adult tissues. Microbiome characterization revealed a high Bacteroidetes to Proteobacteria ratio in healthy animals. Perturbations eliciting an expansion of Proteobacteria coincided with ectopic lesions… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 53 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 103 references

planarians. Developmental Biology 365:458–469

KC Tu, LC Cheng, +4 authors A. Sánchez Alvarado
2015
View 4 Excerpts
Highly Influenced

Cell death and tissue

J Pellettieri, P Fitzgerald, +3 authors A. Sánchez Alvarado
Immunology • 2010
View 4 Excerpts
Highly Influenced

Cell and Developmental Biology 20:725–757

PW Reddien, AL Bermange, KJ Murfitt, JR Jennings, A. Sánchez Alvarado
2005
View 4 Excerpts
Highly Influenced

Structure , function and diversity of the healthy human microbiome

M Karin, H Clevers
Nature • 2016
View 2 Excerpts

Similar Papers

Loading similar papers…