Pathogenic sequence for dissecting aneurysm formation in a hypomorphic polycystic kidney disease 1 mouse model.

@article{Hassane2007PathogenicSF,
  title={Pathogenic sequence for dissecting aneurysm formation in a hypomorphic polycystic kidney disease 1 mouse model.},
  author={Sabrine Hassane and Nanna Claij and Irma S Lantinga-van Leeuwen and Jacoba C. van Munsteren and Natascha A van Lent and Roeland Hanemaaijer and Martijn H. Breuning and Dorien J. M. Peters and Marco C DeRuiter},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2007},
  volume={27 10},
  pages={2177-83}
}
OBJECTIVE Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a multi-system disorder characterized by progressive cyst formation in the kidneys. Serious complications of ADPKD are intracranial and aortic aneurysms. The condition is mainly caused by mutations in the PKD1 or PKD2 gene. We have carefully analyzed vascular remodeling in hypomorphic Pkd1(nl/nL) mouse model with dissecting aneurysms in the aorta. METHODS AND RESULTS Quantitative real-time polymerase chain reaction revealed… CONTINUE READING

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Gene expression profiles in the acutely dissected human aorta

  • BT Muller, O Modlich, +9 authors W. Sandmann
  • Eur J Vasc Endovasc Surg
  • 2002

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