Pathogenic role of anti-endothelial cell antibodies in systemic vasculitis.

  title={Pathogenic role of anti-endothelial cell antibodies in systemic vasculitis.},
  author={Sonja Praprotnik and Bla{\vz} Rozman and Michael Blank and Yehuda Shoenfeld},
  journal={Wiener klinische Wochenschrift},
  volume={112 15-16},
Antiendothelial cell antibodies (AECA), a heterogeneous group of antibodies quite distinct from the ANCA family, have been detected in variety of diseases which share a varying degree of vessel wall damage. This review is mainly focused on Wegener's granulomatosis, Takayasu's arteritis and Kawasaki syndrome, which provide the best examples to evaluate the pathogenic and prognostic value of AECA. There is increasing evidence to show that AECA might be pathogenic in inducing autoimmune vascular… CONTINUE READING


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