Pathogenic role of B-cells in the development of diffuse alveolar hemorrhage induced by pristane

@inproceedings{Barker2011PathogenicRO,
  title={Pathogenic role of B-cells in the development of diffuse alveolar hemorrhage induced by pristane},
  author={Tolga Barker and Pui Y Lee and Kindra M Kelly-Scumpia and Jason S. Weinstein and Dina C. Nacionales and Yutaro Kumagai and Shizuo Akira and Byron P. Croker and Eric S. Sobel and Westley H. Reeves and Minoru Satoh},
  booktitle={Laboratory Investigation},
  year={2011}
}
Diffuse alveolar hemorrhage is an uncommon, yet often fatal, complication of systemic lupus erythematosus (SLE). Advances in the treatment of alveolar hemorrhage have been hampered because of the heterogeneity of clinical findings and the lack of suitable animal models. A single intraperitoneal injection of pristane induces a lupus-like syndrome characterized by lupus-related autoantibodies and glomerulonephritis in non-autoimmune-prone strains of mice. In addition, C57BL/6 (B6) mice frequently… CONTINUE READING

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