Pathogenic role of B-cell receptor signaling and canonical NF-κB activation in mantle cell lymphoma.

@article{Saba2016PathogenicRO,
  title={Pathogenic role of B-cell receptor signaling and canonical NF-κB activation in mantle cell lymphoma.},
  author={Nakhle S. Saba and Delong Liu and Sarah E M Herman and Chingiz Underbayev and Xin Tian and David Behrend and Marc Andr{\'e}e Weniger and Martin Skarzynski and Jennifer A. Gyamfi and Lorena Font{\'a}n and Ari M Melnick and Cliona Grant and Mark Roschewski and Alba Navarro and S{\'i}lvia Be{\`a} and Stefania Pittaluga and Kieron Dunleavy and Wyndham H. Wilson and Adrian Wiestner},
  journal={Blood},
  year={2016},
  volume={128 1},
  pages={
          82-92
        }
}
To interrogate signaling pathways activated in mantle cell lymphoma (MCL) in vivo, we contrasted gene expression profiles of 55 tumor samples isolated from blood and lymph nodes from 43 previously untreated patients with active disease. In addition to lymph nodes, MCL often involves blood, bone marrow, and spleen and is incurable for most patients. Recently, the Bruton tyrosine kinase (BTK) inhibitor ibrutinib demonstrated important clinical activity in MCL. However, the role of specific… CONTINUE READING

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NF-κB signaling and its relevance to the treatment of mantle cell lymphoma

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